Indianapolis will then return home to host the Seattle Seahawks on Oct. 6 for the first time since 2009. In the last meeting between the two teams at Lucas Oil Stadium, Donald Brown and Wayne each found the end zone en route to a 34-17 victory. Overall, the Colts lead the all-time series 6-4, with a 2-1 advantage at home.
The Colts will return to the West Coast on Oct. 14 for their first primetime game of the season with the San Diego Chargers on ESPN’s Monday Night Football. Having lost the previous two games against the Chargers, the Colts will be looking for their first win since a 23-20 victory in 2008. Indianapolis trails in the overall series, 15-9, but holds a 6-4 edge on the road. In their most recent meeting in 2010, the Colts fell to the Chargers, 36-14.
Indianapolis will remain on primetime the following week as it hosts Peyton Manning and the Denver Broncos on NBC’s Sunday Night Football on Oct. 20. The Colts have won the last five matchups with the Broncos dating back to 2005, but trail in the overall series 11-8. At home, the Colts are an even 5-5 against the Broncos, having won 28-26 in the last game at Lucas Oil Stadium in 2009. In their most recent meeting in 2010, the Colts defeated the Broncos by a score of 27-13 at Mile High Stadium.
Following a Week 8 bye, the Colts will again play on Sunday Night Football when they travel to Houston to take on the Texans on Nov. 3. Overall, the Colts hold an 18-4 advantage in the all-time series and are 7-4 on the road. In last year’s game in Houston, the Colts fell 29-17 at Reliant Stadium.
Indianapolis will return home the following week as the St. Louis Rams will visit Lucas Oil Stadium on Nov. 10. The Colts own a 23-17-2 record all-time and a 14-5-2 mark at home against the Rams. The Colts have won the last two matchups dating back to 2005 and have scored more than 40 points in both games. Most recently, the Colts defeated the Rams, 42-6, on Oct. 25, 2009, with Wayne leading the way with seven receptions for 83 yards and a touchdown.