Bethesda opened the second on a 6-2 run, finished strong with a 9-0 spurt and led 20-8 at the half.
Warrick scored 10 of her game-high in the second as Bethesda carried momentum into the break. Metro shot 3 of 35 for the half.
Bethesda extended its lead in the third by 17 points and cruised to victory through the fourth.
Bethesda will take on Indiana Math and Science following Game 1 at approximately 11:45 a.m. Saturday with the final set at 8 p.m. if the Patriots advance. Bethesda downed Indiana Math and Science 41-19 on Feb. 6.
— Follow Hendricks County Flyer sports editor Jake Thompson on Twitter @JacobEThompson.